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ritonavir will increase the amount or impact of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.elvitegravir/cobicistat/emtricitabine/tenofovir DF raises amounts of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.Most patients do establish hypoglycemia, so lessening the dose with the or